“Whatever the field is, it’s been a long journey—decades of learning how to do things better, and it doesn’t mean we stop learning. VeloSano allows us to keep moving the field forward.”
While treatments for many cancers have advanced significantly over the years, there are challenges that remain. For example, diffuse large B-cell lymphoma (DLBCL), a type of blood cancer that affects the lymphatic system, is often highly treatable. However, for some patients, current therapies are less effective, highlighting the need for continued research and innovation.
Recognizing this need, Brian Hill, MD, PhD, applied for a VeloSano grant to launch a clinical trial testing a new drug in combination with the standard frontline treatment for DLBCL. The drug, called Zanubrutinib, works differently than traditional chemotherapy. It blocks a signal inside the cancer cells that normally tells them to grow and divide.
“Zanubrutinib switches off the switch inside the large B-cell lymphoma cancer cells,” says Dr. Hill, who also serves as Director of the Lymphoid Malignancies Program at Cleveland Clinic. “Our idea is that we’re going to eliminate more of the cancer cells with this combination, and we believe it will be safe because we have already seen data showing this can be given safely together.”
Dr. Hill divides his time between caring for patients and leading innovative clinical research to develop new treatment options. His work bridges patient care and scientific discovery, bringing hope to patients today while shaping the therapies of tomorrow. A longtime supporter of VeloSano, Dr. Hill has witnessed firsthand the difference it makes in accelerating cancer research.
“In my career, I have seen how my patients have benefited from research,” says Dr. Hill. “People who are alive today may not have been if they were treated 10 years ago because of the advances. Seeing the impact at a human level of what we do and why we do it really provides a lot of inspiration for those who are involved in this.”
When it comes to getting involved, Dr. Hill has been involved with Bike to Cure since year one. His longstanding commitment to the event reflects not only his passion for advancing cancer research but also his belief in the power of community-driven efforts to make a meaningful impact.
“I think it’s amazing,” says Dr. Hill. “The kickoff party is a lot of fun. It’s exciting to see the anticipation of the big day with the bikes all lined up. There’s music and food, and you get to hear patients’ stories. It’s really a wonderful event.”
100% For The Cure
